




















Matthew D'Ursov

Amy Leifeste

Karena Mathis
Matthew D'Ursov
Amy Leifeste
Karena Mathis
All of the information on this page has been reviewed and verified by a certified addiction professional.
Datura, commonly known as Devil’s Trumpet, is a highly toxic weed with hallucinogenic properties, severe side effects, and a history of recreational abuse. Containing potent alkaloids like atropine, hyoscyamine, and scopolamine, it can cause serious health issues, including delirium, psychosis, and death. While historically used for medicinal and religious purposes, its extreme toxicity makes it dangerous for use [1].
A member of the nightshade family (Solanaceae), datura is recognized by its striking white or purple flowers and thorny seed pods. All parts of the plant—especially the seeds and leaves—are poisonous due to their high alkaloid content. This article explores datura’s chemical composition, historical uses, effects, and associated dangers, including hallucinations and psychosis.
Datura is a naturally occurring hallucinogenic plant containing alkaloids that induce extreme delirium, disorientation, and harmful physical effects. Known as Devil’s Trumpet, it has a historical reputation for medicinal use but is now primarily associated with recreational abuse due to its psychotropic effects. Its high risk of poisoning and overdose has led to bans in many regions, as abuse often results in hospitalization from unpredictable effects, including respiratory and cardiac complications.
Datura contains powerful alkaloids—atropine, hyoscyamine, and scopolamine—that act on the central nervous system by inhibiting acetylcholine, a neurotransmitter critical for muscle control, memory, and brain function [2].
Atropine: Causes hallucinations, rapid heart rate, and confusion.
Scopolamine: Leads to profound confusion, amnesia, and sedation.
Hyoscyamine: Results in dry mouth, blurred vision, and potential psychosis.
These alkaloids are most concentrated in the seeds of datura, but all parts of the plant, including its flowers, are toxic.
Historically, datura has been used for medicinal and spiritual purposes, though its modern use is limited due to its unpredictable potency and deadly side effects.
Spiritual Rituals: Certain cultures used datura in rituals to induce visions or spiritual experiences.
Pain and Respiratory Relief: In traditional practices, small amounts were smoked or applied topically for pain or asthma relief.
Recreational Abuse: Some seek a “datura trip” for its hallucinogenic effects, but the line between intoxication and dangerous poisoning is extremely thin, making such use highly unsafe.
Datura is known by various names worldwide. These include:
Devil’s trumpet
Jimsonweed
Thorn apple
Moonflower
Angel’s trumpet (which is usually confused with Brugmansia species)
Yes, datura is extremely toxic, and even small doses can cause severe poisoning or death, with the seeds being particularly dangerous.
Symptoms of datura poisoning include:
Dilated pupils and blurred vision
Elevated blood pressure and heart rate
Dry mouth and urinary retention
Severe confusion, delirium, and agitation
Seizures, coma, or death in extreme cases
Due to its unpredictable and potent effects, experimentation or self-administration of datura is highly dangerous and potentially fatal.
Intense hallucinations, confusion, and disorientation. Unlike other hallucinogens, datura hallucinations are often vivid and disorienting, making it difficult to distinguish reality from fantasy.
Users commonly describe the experience as unpleasant, terrifying, and unstable, marked by confusion, fear, and amnesia rather than euphoria. Medical professionals strongly discourage recreational use due to these severe risks [3].
Datura’s physical effects range from mild discomfort to life-threatening emergencies, typically beginning within an hour of ingestion and lasting 24 to 48 hours, making it one of the longest-lasting and most dangerous plant-based intoxicants.
Common physical effects include:
Dry, flushed skin (due to inhibited sweating)
Dilated pupils and impaired vision
Rapid heart rate (tachycardia)
Difficulty urinating
Seizures or tremors
Nausea and vomiting
Datura’s alkaloids severely disrupt brain function, leading to devastating cognitive and psychological effects, including datura psychosis, confusion, and memory loss.
Common mental effects include:
Severe disorientation and inability to recognize surroundings
Vivid, frightening hallucinations
Delirium and paranoia
Short-term memory loss
Impaired judgment
Unlike hallucinogens like LSD or psilocybin, which may produce clarity or insight, datura typically induces anxiety, confusion, and risky behavior, making it particularly dangerous.
A datura trip is often described as terrifying and highly dangerous. Datura hallucinations are vivid, dream-like, and interactive, making it nearly impossible for users to distinguish reality from fantasy.
Users may experience datura psychosis, leading to irrational or dangerous behavior.
Trips can last for days, increasing risks of dehydration, disorientation, or getting lost.
Medical intervention is often required due to the severe and unpredictable nature of datura drug effects.
Yes, repeated datura use can lead to permanent mental impairment and psychological disorders. Prolonged exposure to its toxic alkaloids may cause nerve damage, long-term memory loss, and chronic psychopathology [3].
Safety and Prevention
Is datura toxic? Datura is highly toxic, and awareness is critical for prevention. Misidentification of the datura plant or accidental ingestion of its seeds has led to numerous poisonings worldwide.
Prevention Tips:
Avoid using or experimenting with any part of the datura plant.
Educate others about the dangers of datura drug effects.
Seek immediate medical attention if poisoning is suspected.
The datura plant, including its flowers and seeds, contains potent alkaloids—atropine, scopolamine, and hyoscyamine—that cause unpredictable and toxic effects. Despite its innocent appearance, datura is highly toxic and can result in hallucinations, psychosis, and death. Understanding these risks is essential to avoid their life-threatening consequences.
Datura’s effects, both physical and psychological, can last for days, often causing users to lose all sense of time and place. Unlike other hallucinogens, datura trips are typically marked by fear, confusion, and delirium rather than euphoria.
Datura’s short-term effects include intense hallucinations, confusion, and life-threatening physical responses, often starting within minutes due to the rapid absorption of its toxic alkaloids [4].
Common short-term effects include:
Severe Hallucinations: Users experience vivid, frightening hallucinations, unable to distinguish reality from fantasy.
Confusion and Euphoria: Users may act erratically, endangering themselves or others.
Physical Effects: Rapid heart rate (tachycardia), dry mouth, flushed skin, dilated pupils, and blurred vision.
Respiratory Complications: Datura disrupts the nervous system, potentially causing dangerous breathing issues.
Risky Behavior: Intoxication may lead to wandering into dangerous areas, accidents, or self-injury.
These effects can persist for 48 hours or longer, often requiring emergency medical attention.
Long-term datura use can lead to catastrophic physical and psychological consequences, including chronic health issues:
Cognitive Impairment: Persistent memory problems, confusion, and reduced concentration.
Chronic Anxiety and Depression: Datura’s impact on neurotransmitters can cause ongoing emotional instability.
Organ Damage: Repeated use may harm the liver, kidneys, and heart.
Neurological Issues: Chronic exposure impairs judgment and mental clarity.
Risk of Psychosis: Prolonged abuse can lead to persistent hallucinations and paranoia, known as datura psychosis
These effects may last for months or become permanent, depending on the extent of exposure.
Datura disrupts brain function by inhibiting acetylcholine, a neurotransmitter critical for memory, muscle movement, and alertness, resulting in a dangerous mix of confusion, hallucinations, and amnesia.
Hallucinations: Vivid and intense, often leading to risky behavior.
Cognitive Disruption: Severe impairment of reality processing, causing delusional thinking.
Memory Loss: Most users experience amnesia during a datura trip, increasing its dangers.
Emotional Instability: Effects include heightened anxiety, paranoia, and emotional blunting.
These neurological impacts make the use of datura strongly discouraged by medical professionals.
Datura is one of the most dangerous hallucinogenic substances due to its narrow margin between a psychoactive dose and a lethal one. Unlike other recreational drugs, datura’s toxic alkaloids are difficult to dose safely, making any use highly risky.
Datura overdose is extremely dangerous, with even small amounts of its flowers or seeds causing severe toxicity within 30 to 60 minutes. Symptoms of overdose include:
Symptoms of overdose include:
Severe agitation and confusion
Extremely high heart rate and blood pressure
Seizures and tremors
Shortness of breath
Coma or unresponsiveness
Due to the prolonged duration of datura’s effects (hours to days), overdose symptoms can escalate rapidly, often requiring hospitalization. Medical literature documents cases of poisoning from misidentifying datura or underestimating its potency.
While datura is not classically addictive, its hallucinogenic effects can lead to psychological dependence in some users. Signs of dependence include:
Indications of psychological dependence are:
Preoccupation with having a datura trip
Recurrent use despite the adverse effects
Employing datura flowers or seeds specifically for abuse
Behavioral changes related to substance pursuit
This cycle increases the risk of accidental overdose, as users may take higher doses to replicate past experiences, unaware of the plant’s unpredictable potency.
Yes, datura can be fatal, even in small doses. Its poisonous alkaloids disrupt the nervous system, potentially causing respiratory failure, cardiac arrest, or severe dehydration [5].
Fatalities are often linked to:
Consuming large quantities of datura seeds
Combining datura with alcohol or other drugs
Delayed medical intervention during an intense datura trip
CDC reports and medical literature confirm numerous global deaths from accidental or intentional datura poisoning.
The primary danger of datura lies in its unpredictability—alkaloid concentrations vary significantly between plants and even within different parts of the same plant, making safe dosing impossible. Effects can last up to 72 hours, increasing risks of accidents, dehydration, and medical emergencies. Unlike other hallucinogens, datura trips are typically terrifying and traumatic.
Early recognition of datura poisoning can be lifesaving.
Key symptoms include:
Dilated pupils and blurred vision
Hot, dry skin and inability to sweat
Confusion, delirium, and severe restlessness
Hallucinations and paranoia
Rapid heartbeat or chest pain
If these signs are present, seek emergency medical help immediately. The longer datura’s toxins remain in the system, the greater the risk of life-threatening complications.
Q1: What drug is derived from datura?
Datura contains toxic alkaloids—atropine, scopolamine, and hyoscyamine—that produce its hallucinogenic, confusional, and delirious effects. In rare, medically controlled settings, these compounds may be used as anesthetics or for the treatment of motion sickness. However, the raw datura plant is extremely toxic and dangerous for recreational use.
Q2: Is datura illegal in the US?
Datura is not federally regulated in the United States, but its use is strongly discouraged due to its toxicity. Some states and municipalities have laws prohibiting the sale or cultivation of datura for non-ornamental purposes because of its toxic and hallucinogenic risks.
Q3: What is the street name for datura?
Common street names for datura include “Devil’s Trumpet,” “Devil’s Weed,” and “Jimsonweed.” These names refer to the datura plant, including its flowers and seeds, which are notorious for producing unpredictable and dangerous hallucinations.
Q4: What did Native Americans use datura for?
Historically, Native Americans used datura in small, carefully controlled amounts for religious rituals and medicinal purposes. They were well aware of its toxicity and the severe risks of misuse, requiring meticulous preparation to avoid poisoning.
If you or someone you care about is misusing datura—whether its seeds, flowers, or other parts of the plant—immediate professional medical help is essential. Datura is highly toxic, capable of causing severe poisoning, hallucinations, and permanent mental damage.
Alliance Recovery offers specialized support for individuals affected by harmful substances like datura. Their experienced professionals provide medically supervised detox, emergency care, and personalized treatment plans to ensure safe recovery and prevent further harm.
Call our treatment team at (844) 287-8506 to get started.
Sources
[1]. https://pmc.ncbi.nlm.nih.gov/articles/PMC3621465/
[2]. https://pmc.ncbi.nlm.nih.gov/articles/PMC4909958/?utm
[3]. https://pmc.ncbi.nlm.nih.gov/articles/PMC6767831/
[4]. https://pmc.ncbi.nlm.nih.gov/articles/PMC5555431/?utm
[5]. https://www.cdc.gov/mmwr/preview/mmwrhtml/00035694.htm?utm









