Hydrocodone/Oxycodone Overdose: Signs, Symptoms

Authored By:

Matthew D'Ursov

Edited By:

Amy Leifeste

Medically Reviewed By

Karena Mathis

Authored By:

Matthew D'Ursov

Edited By:

Amy Leifeste

Medically Reviewed By

Karena Mathis

All of the information on this page has been reviewed and verified by a certified addiction professional.

Hydrocodone/Oxycodone Overdose: Signs, Symptoms

A hydrocodone/oxycodone overdose can occur when someone takes too much of these powerful opioid medications, leading to life-threatening effects. These drugs, used for pain relief, can cause severe symptoms like slow breathing or unconsciousness if misused.

This article covers the dangerous ingredients, alternative names, overdose symptoms, and what to do in an emergency. 

Poisonous Ingredient in Hydrocodone/Oxycodone

Hydrocodone and oxycodone contain opioid compounds that relieve pain but can be dangerous in high doses. These compounds act on the brain and spinal cord to reduce pain signals but can slow breathing, cause heart issues, or lead to dependence. They also affect the brain’s reward system, increasing the risk of addiction or a hydrocodone/oxycodone overdose. Non-opioid components, like acetaminophen in Percocet or ibuprofen in Vicoprofen, can harm the liver or kidneys in high doses, doubling the overdose risk. Careful use under medical supervision is essential to avoid these dangers. [1] 

Hydrocodone and Oxycodone

Hydrocodone and oxycodone are opioid medications used to treat severe pain when other painkillers aren’t enough. They work by acting on the brain and spinal cord to reduce pain signals, providing relief for conditions like post-surgical pain or chronic pain. However, taking excessive hydrocodone or oxycodone can lead to a hydrocodone/oxycodone overdose, causing serious harm. These drugs can cause dependence and are tightly controlled due to their risk of misuse. Doctors prescribe them carefully to avoid addiction or overdose. 

Hydrocodone – Common Uses and Brand Names

Hydrocodone is used to treat moderate to severe pain, such as after surgery, dental procedures, or injuries. It’s sometimes prescribed for severe coughs. Often combined with acetaminophen or ibuprofen to enhance pain relief, hydrocodone is found in: 

 

  • Vicodin – hydrocodone mixed with acetaminophen. 

  • Norco – hydrocodone with acetaminophen, often in smaller doses. 

  • Lortab – hydrocodone with acetaminophen in tablet or liquid form. 

  • Vicoprofen– hydrocodone with ibuprofen.

Doctors select a brand based on the patient’s pain and health needs, avoiding ibuprofen for those with certain conditions. Hydrocodone’s risk of addiction and hydrocodone overdose requires short-term use and close medical supervision. [2]

Oxycodone – Common Uses and Brand Names

Oxycodone is prescribed for severe pain, like post-surgical, cancer, or arthritis pain, when other medications fail. It comes as a single drug or combined with others, in immediate-release or extended-release forms. Immediate-release medications work quickly but wear off faster, while extended-release medications provide longer relief [3]. 

 

Brands include: 

  • OxyContin – extended-release oxycodone for long-lasting relief. 

  • Percocet – oxycodone mixed with acetaminophen. 

  • Roxicodone – immediate-release oxycodone for quick action. 

  • Percodan – oxycodone mixed with aspirin.

Doctors choose the form based on the duration and intensity of the pain. Taking excessive amounts of oxycodone or mixing it with alcohol or sedatives can lead to an oxycodone overdose, slow breathing, and potentially cause death. Prescriptions are carefully monitored to prevent misuse and abuse. [4]

Active Opioid Compounds

Hydrocodone and oxycodone are opioid medications that effectively reduce pain by soothing the brain. However, they also come with significant risks. These medications can slow down breathing, potentially resulting in an insufficient oxygen supply to the brain. Furthermore, excessive use can damage the heart and may even lead to death.

 

Opioids also stimulate the brain’s reward system, providing a temporary sense of pleasure or calmness. This can lead to cravings and, over time, the need for larger doses, resulting in habit formation and addiction. So, the very thing that helps with pain is also the main poison when used in the wrong way.

Risk of Combination Drugs

In many cases, hydrocodone and oxycodone are mixed with other drugs. These are not opioids, but they carry their own harms.

 

  • Acetaminophen is used for pain and fever relief, but excessive amounts can damage the liver or cause liver failure.

  • Ibuprofen helps with swelling and pain, but excessive use can harm the stomach, kidneys, or heart, potentially leading to ulcers or bleeding.

 

When combined with opioids, the risks increase significantly, as the body has to manage both the opioid effects and the dangers of additional medications, raising the likelihood of overdose.

Alternatives Names

Hydrocodone and oxycodone are known by street names that vary by region or group. These names often reflect the drug’s brand, appearance, or effects: 

 

  • Hydrocodone: Vikes, Hydros, Tabs, Fluff, V-itamin, Vic, Watson-387. 

  • Oxycodone: Oxys, Percs, O.C., Roxys, Cotton, Hillbilly heroin, OX, Oxycet, Oxycotton.

Symptoms of Hydrocodone and Oxycodone Overdose

A hydrocodone/oxycodone overdose causes severe symptoms that affect the body and mind, requiring immediate action. Signs may start mild but can worsen quickly, especially with high doses. Recognizing these symptoms early can prevent life-threatening outcomes like coma or death. Below are the key physical, mental, and severe signs of an overdose. These signs are critical to identify, as a hydrocodone or oxycodone overdose can escalate rapidly. 

Physical Symptoms

Physical symptoms of a hydrocodone/oxycodone overdose appear early, showing the body is struggling. 

 

These include: 

  • Slow or shallow breathing, where the chest barely moves. 

  • Extreme drowsiness can make it hard to stay awake. 

  • Cold, clammy, or pale skin.


These signs indicate the lungs and nervous system are under stress. If untreated, they can lead to a fatal hydrocodone or oxycodone overdose. Seek help immediately to prevent serious harm. [1]

Mental and Behavioral Symptoms

An opioid overdose can also bring changes to the brain and behavior. Such mental and behavioral symptoms may include-

 

  • Confusion or delirium, where thoughts are unclear or nonsensical. 

  • Unresponsiveness, where the person doesn’t react to sound or touch.

 

These occur because opioids slow brain activity, causing disorientation or detachment. Immediate care is needed to prevent worsening, especially in a hydrocodone/oxycodone overdose. 

Severe Warning Signs

In very high doses, hydrocodone or oxycodone overdose can lead to severe warning signs. These are the most dangerous, and they must be treated as an emergency. Some of them are–

 

  • Blue lips or fingernails, showing low oxygen in the blood. 

  • Loss of consciousness, where the person doesn’t move or wake up.

 

These show the body is shutting down, risking coma or death. Call 911 immediately if these appear to prevent a fatal overdose.

What To Do If Someone is Overdosing

If someone is experiencing a hydrocodone/oxycodone overdose, act quickly to save their life. The body can shut down rapidly, so immediate steps are critical. Below are actions to take during an overdose emergency, including using naloxone and providing first aid. Quick response can prevent a fatal hydrocodone or oxycodone overdose.  

Immediate Steps

Immediate steps are the first things one must take the moment an overdose is suspected. These include–

 

  • Call 911 right away, telling them it’s an opioid overdose. 

  • Give naloxone (Narcan) if available, to reverse opioid effects and restore breathing.

 

These steps connect the person to emergency care and can reverse life-threatening effects. Act fast to prevent a fatal hydrocodone/oxycodone overdose. Naloxone can be a lifesaver when used promptly.

First Aid While Waiting

While waiting for emergency help, it is essential to provide basic support so the person’s body can continue to function. Some actions are–

 

  • Perform rescue breathing or CPR if the person stops breathing. 

  • Keep the person awake if possible by gently shaking or speaking loudly. 

  • Place the person in the recovery position, lying on their side with their head tilted, to keep the airway clear.

 

These actions give the brain and body a chance to survive until experts arrive. Though they may look simple, they can mean the difference between life and death.

FAQs

Can Percocet kill you?

Yes, a Percocet overdose, which contains oxycodone, can be fatal if untreated. It causes slow breathing, unconsciousness, or low oxygen, leading to death. Immediate medical care and naloxone can reverse these effects. Mixing Percocet with other substances increases the risk of a fatal oxycodone overdose. 

 

How much oxycodone is too much?

Doses above 40 mg of oxycodone at once or 80 mg daily for adults risk an oxycodone overdose, though this varies by person. Prescribed doses are typically lower, and exceeding them can cause severe symptoms. Always follow a doctor’s guidance to avoid dangerous outcomes.  

 

What are the symptoms of a hydrocodone/oxycodone overdose?

Symptoms of a hydrocodone/oxycodone overdose include slow breathing, extreme drowsiness, confusion, blue lips, or unconsciousness. These signs can worsen rapidly, requiring urgent medical attention.  

 

Is hydrocodone a Percocet?

No, hydrocodone is not Percocet; it’s a different opioid, though both are used for pain. Percocet contains oxycodone and acetaminophen. Mixing hydrocodone and oxycodone increases the risk of a hydrocodone/oxycodone overdose, so they should never be combined without medical advice. 

Get Treatment for Hydrocodone Addiction at Alliance Recovery

If you or a loved one is struggling with Hydrocodone addiction, do not wait to get the help you need. Our experienced treatment team is here to guide you on the path to recovery, with evidence-based treatments, compassionate care, and effective treatments.

 

Here at Alliance Recovery, our executive leadership and admissions staff have extensive knowledge of addiction treatment, with many members of our team having gone through treatment themselves. Through years of their lives dedicated to service and striving to develop a connection with fellow addicts, our team has cultivated a passion for helping others who find themselves in the same position.

 

When you come to Alliance Recovery, you’ll experience:

  • Real, genuine care from people who understand you.

  • Evidence-based treatment programs.

  • Individual and group therapy sessions.

  • Personalized treatment plans.

  • Supportive sober community and treatment staff.

  • Aftercare and career placement.

 

Start your journey to recovery today. Call our treatment team at (844) 287-8506 to get started.

Sources

[1]https://www.ncbi.nlm.nih.gov/books/NBK537288/

[2]https://medlineplus.gov/druginfo/meds/a601006.html

[3]https://www.mayoclinic.org/drugs-supplements/oxycodone-oral-route/description/drg-20074193

[4]https://medlineplus.gov/druginfo/meds/a682132.html

[5]https://medlineplus.gov/ency/patientinstructions/000798.htm

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