Uses, Side Effects, and More on Seroquel
The generic name of Seroquel is Quetiapine. Seroquel is an antipsychotic medication most commonly prescribed for varying mental health conditions. Seroquel is commonly prescribed for bipolar disorder and schizophrenia and is mainly a treatment prescribed for depressive disorders [1].
As a member of the Seroquel drug class of atypical antipsychotics, it works by controlling brain chemistry to subdue an individual’s signs of depression and moods, and hallucinations. Most patients benefit from it; however, there are likely side effects and cautions that should be considered before its use.
In this article, we will explore the uses of Seroquel, its mechanism of action, dosage forms, storage instructions, common and serious side effects, as well as important warnings and precautions to be aware of.
Uses
Seroquel is an atypical antipsychotic medication that is predominantly used to treat psychiatric disorders. Its principal indications are:
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Schizophrenia: It improves concentration by decreasing hallucinations, alleviating confusion, and balancing chemicals in the brain.
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Bipolar disorder:
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Manic episodes.
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Depressed episodes
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Maintenance treatment
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Major depressive disorder (MDD): Constant depression is used as an auxiliary treatment with antidepressants.
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General anxiety and sleep disorder (off-labeled): Sometimes, its sedative properties are prescribed off-label for anxiety and insomnia.
What is Seroquel Used For?
Seroquel is indicated in the therapy of schizophrenia, bipolar disorder (both manic and depressive stages), and major depressive disorder (add-on therapy). People with schizophrenia have decreased symptoms, such as hallucinations, disorganized thinking, and difficulty returning to social contact. In contrast, in bipolar disorder, seroquel is indicated for the acute stage of mania, depression, and also long-term stabilization of mood. [2]
In most current textbooks, this drug is not considered a first-line medication for major depressive disorders, but can be added when the main treatment is insufficient.
How does Seroquel work (mechanism of action)?
Seroquel enhances its effect by modulating the action of certain neurotransmitters within the brain, specifically dopamine and serotonin. An atypical antipsychotic, it blocks some dopamine (D2) and serotonin (5-HT2) receptors. This reduced the function of the organic brain, stabilized mood, lessened mental signs and symptoms, and increased general clarity of thought.
Unlike chronic antipsychotics, it is unlikely to produce movement disorders related to Seroquel (extrapyramidal symptoms); however, it may cause an unconscious condition and metabolic side effects from its influence on histamine and adrenergic receptors.
Doctors may even prescribe Seroquel off-label for such conditions as generalized anxiety disorders, insomnia, or post-traumatic stress disorder (PTSD). Such uses, however, should be closely monitored for Seroquel Side Effects.
How is Seroquel supplied (described in dosage form)?
Seroquel is available in immediate-release and extended-release (XR) tablet forms, with strengths ranging from 25 mg to 400 mg. [2]. Immediate-acting ones are usually administered in 2 or 3 doses within 24 hours, while the XR is given once daily, preferably at night. The dosage of Seroquel is determined by the treatment indications, symptom severity, and patient responses.
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Schizophrenia: Generally, the starting dose is 25 mg twice a day, followed later by increasing it to 300-400 mg daily.
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Bipolar disorder: They can start at 50 mg/day but will be up to a ceiling of 400-800 mg daily.
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Depression (adjunct treatment): Initiated from a low dose of 150-300 mg/day.
Patients should strictly adhere to their doctor’s guidance and never alter their Seroquel doses without consulting a physician [2].
How do I store Seroquel?
Seroquel must also be stored at room temperature, ranging from 20 °C to 25 °C (68 °F to 77 °F), in a dry, cool environment, protected from moisture, heat, and sunlight [3]. The tablets are ideally stored inside the original container to maintain their stability. Always keep the medicine out of the reach of children and animals. An expired Seroquel should never be used since it loses its potency.
Side effects
Seroquel (Quetiapine) can cause many side effects, like drowsiness, dizziness, dry mouth, and weight gain. Increased appetite with occasional constipation is mostly experienced by most people taking the drug, especially if they are on it for the first time. All these side effects, though manageable, can bring loneliness, and some individuals may develop severe symptoms such as rapid heart rate, different mood changes, or appear to have signs of movement disorders like uncontrolled body or face movements.
What Are the Common Side Effects of Seroquel?
Common side effects of Seroquel include drowsiness, dry mouth, dizziness, weight gain, constipation, and increased appetite [4]. These effects are mild and typically diminish over time as the body becomes accustomed to the medication. Even so, patients should be vigilant for any changes and keep their healthcare provider informed.
Other side effects commonly reported include:
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Fatigue and sedation (especially upon initiation of the medication)
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Headache
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Dizziness upon sudden standing
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Light stomach upset
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Since Seroquel is a sedative, taking it with alcohol will increase sleepiness and should be avoided.
What are a few Serious Side Effects of Seroquel?
High blood sugar, weight gain, neuroleptic malignant syndrome, and tardive dyskinesia are some associated serious side effects of Seroquel [4]. People with diabetes or who are considered at risk of having metabolic syndrome should thus be closely observed, as Seroquel may increase blood sugar levels.
Major warning signs of serious adverse effects are:
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Sudden muscle stiffness, confusion, or sweat (symptomology indicative of neuroleptic malignant syndrome)
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Involuntary movements of the body
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Sudden changes of mood or suicidal ideation (common in the younger populations)
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Vision
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Severe allergic reactions such as rash, swelling, and difficulty in breathing.
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Should any of these be borne, they should be sought immediately.
Warnings and Precautions
Before beginning or completing treatment, patients should be aware of the numerous significant warnings and precautions associated with seroquel (quetiapine). Because of the higher risk of death, this medication has not been authorized for use in older patients who have psychiatric psychosis. Additionally, it may raise the likelihood of suicidal thoughts or actions, particularly in teenagers and young adults.
Who should not use Seroquel?
Seroquel should not be administered to patients who are allergic to quetiapine or any other ingredients in the drug. Patients with psychosis associated with elderly dementia should not be determined, as there is a higher risk of death. Patients with a previous history of heart disease, convulsions, liver disorders, or low white blood cell count should take Seroquel with special care [5].
Pregnant or breastfeeding women should take the opinion of a physician before the administration of Seroquel, as it can pose a threat to the baby.
What should I know before using Seroquel?
Before taking Seroquel, one must know about risks and drug interactions. Seroquel may interact with other drugs, such as some antidepressants, antifungals, or blood pressure drugs. Mixing Seroquel and alcohol or sedatives can cause a person to experience prolonged drowsiness and poor coordination.
Patients should know that if the drug is suddenly discontinued, they are at risk for a return of Seroquel. Nausea, insomnia, and irritability can occur. To prevent the return, the dose must be administered in a doctor-supervised setting.
What should I tell my Healthcare Provider before using Seroquel?
Before starting Seroquel, inform your healthcare provider about your complete medical history and any medicines or supplements that you are currently taking [5]. In particular, discuss:
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Any history of heart problems or unusual heart rhythm
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Seizure disorder
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Liver or kidney issues
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Previous allergic reactions to antiseptic drugs
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Use of alcohol or recreational drugs
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Whether you are pregnant, planning to get pregnant, or breastfeeding
Complete disclosure helps your provider determine whether seroquel is the right medicine for you and adjust your Seroquel dose as required.
Interaction
Seroquel, also known as quetiapine, is an atypical antipsychotic medication used to treat major depressive disorders, bipolar disorder, and schizophrenia. Like many prescription medications, Seroquel may interact with certain foods, beverages, and other medications, potentially reducing its effectiveness or increasing the risk of adverse side effects [6].
Are there any Food or Drink Interactions with Seroquel?
Yes, Seroquel interacts with certain foods and beverages, whose absorption may be altered, and with it, the risk of side effects increases. [6] Quetiapine metabolism in the body can be inhibited by grapefruit and grapefruit juice, which may elevate the medication’s blood sugar levels. This situation may increase the risk of serious side effects of Seroquel, such as fatigue, hypotension, or irregular heartbeats.
Alcohol is another important issue. Seroquel and alcohol should not be used simultaneously, as alcohol will increase the effect of seroquel as a sedative [6]. When used simultaneously, it can result in excessive drowsiness, impaired coordination, confusion, or severe breathing difficulties.
While taking Seroquel, it is advised that:
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Leave grapefruit or grapefruit products.
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Drink very little or no alcohol.
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Take the drug as directed, which usually occurs with or without food, but always in the same fashion every day.
Heavy meals may slightly alter the way seroquel is absorbed, but this is usually not clinically relevant. Nevertheless, patients should always follow the special instructions provided by their doctor [6].
Does Seroquel Interact with Other Drugs or Medications?
Yes, Seroquel interacts with many other drugs, resulting in harmful side effects or a deficiency in efficacy [7]. Seroquel is a typical antipsychotic drug affecting brain neurotransmitters. Conversations with other sedating drugs or drugs with a similar metabolic profile may increase the risk of adverse effects.
Important Interactions are:
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Antifungal and antibiotics: Ketoconazole or erythromycin can raise blood concentrations and may cause poisoning.
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Anticonvulsant to Phenobarbital: Phenytoin and carbamazepine will eventually counteract the effectiveness of Seroquel.
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Drug for high blood pressure: Side effects of Seroquel, particularly when used in conjunction with antihypertensive drugs, may include dizziness or fainting due to changes in blood pressure.
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Other psychiatric drugs: Seroquel and other antipsychotics or antidepressants. Use together may result in serotonin syndrome, extrapyramidal syndromes, or other kinds of adverse effects.
Patients should provide their doctors with all their medical prescriptions, over-the-counter medications, and supplements they are currently taking. This includes some herbal supplements such as St. John’s Wort, which can reduce the efficacy of the drug [7]. Knowledge of drug interactions is important to ensure the safe use of seroquel.
Overdose/missed dose
Excessive use of Seroquel (quetiapine) can have serious and possibly fatal side effects. Symptoms of overdose may include extreme sleepiness, racing heart, low blood pressure, fainting, or coma. In extreme cases, it may cause respiratory depression or cardiac arrhythmias. Urgent medical attention must be sought in the event of any suspected overdose.
What should I do if I accidentally use too much Seroquel?
You should call emergency medical personnel immediately. The signs of an overdose are: excessive sleepiness, fainting, a fast pulse, confusion, seizures, or even a coma.
You could overdose on seroquel if you are over the recommended dose or combine the drug with alcohol or other sleep aids. If overdose is suspected:
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Call emergency services (911 in the USA).
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If available, call a poison control center for immediate advice.
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Don’t induce vomiting without medical advice.
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Stay with the person until help arrives and keep the airway clear.
The treatment of a seroquel overdose in the hospital may include auxiliary therapy such as heart function, oxygen therapy, IV fluid, and drug monitoring for managing blood pressure or seizures [9]. It is important to find immediate medical intervention to avoid severe consequences or even death.
What should I do if I miss a dose of quetiapine?
If you forget to take a dose of Seroquel, take it as soon as possible, but not before your next scheduled dose. If so, leave the missed dose and return to your regular dose schedule. Never double the dose for a missed dose, as it increases the risk of side effects such as dizziness, extremely unconscious action, or unusual heart rhythm.
Tips for avoiding missing doses:
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Set an alarm or reminder on your phone.
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Putting the drug in a visible place (but out of reach of children).
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Using a tablet organizer to track your daily dose.
Regular use of seroquel is necessary as directed to manage conditions such as schizophrenia or bipolar disorder. Missing or skipping multiple doses can result in the return of or increase the risk of nausea, insomnia, or irritability.
FAQ’S
Q1: What is the primary purpose of Seroquel?
Seroquel primarily helps in fixing up disorders of the mind, such as major depressive disorder, bipolar disorder, and schizophrenia. This medicine alleviates certain symptoms like dreadful mood swings, hallucinations, and feelings of depression by regulating certain neurotransmitters in the brain.
Q2: Does Seroquel resemble Xanax?
Seroquel and Xanax cannot be compared as their functions are different. Although both medications are sedatives, Xanax (alprazolam) is a benzodiazepine, whereas Seroquel (quetiapine) is an atypical antipsychotic. They differ in the diseases treated. Both types have different effects on the brain. Xanax works for all forms of anxiety and nervous disorders, whereas Seroquel treats mental illness and mood stabilization.
Q3: What are the disadvantages of Seroquel?
Seroquel is notorious for milder or severe side effects. Patients frequently complain of weight gain, dry mouth, dizziness, and drowsiness as side effects of Seroquel. Some of the most severe adverse effects include neuromuscular problems, elevated blood sugar levels, and altered cholesterol levels. Long-term usage also increases one’s chances of metabolic syndrome and cardiovascular disease.
Q4: Is Seroquel a downer or an upper?
Seroquel cools and soothes hyperactive brain activity, which makes it a “downer.” Seroquel may make you feel comfortable or at ease while lowering anxiety and movement. It should not be confused with drugs that are uppers, but this is why it is occasionally prescribed for insomnia or restless sleep.
Get Help for Seroquel Misuse and Recovery
If you or someone you care about is misusing Seroquel, it is necessary to seek professional assistance. Seroquel works well for the treatment of mental illnesses, but abuse results in severe side effects, addiction, or fatal complications.
Alliance Recovery provides special treatment for patients who have problems with opioid drug abuse, such as seroquel. Their experienced team securely provides medical monitoring, detoxification, withdrawal management, and adapted long-term recovery facilities, as well as personalised treatment programs to increase mental health.
Call our treatment team at (844) 287-8506 to get started.
Sources
[1]. https://www.drugs.com/seroquel.html
[2]. https://www.healthline.com/health/drugs/seroquel-dosage#seroquel-vs-seroquel-xr-dosage
[3]. https://www.drugs.com/pro/seroquel.html?utm
[4]. https://www.drugs.com/sfx/seroquel-side-effects.html
[5]. https://www.rxlist.com/seroquel-drug.htm#indications
[6]. https://www.drugs.com/food-interactions/quetiapine.html
[7]. https://www.drugs.com/drug-interactions/quetiapine-index.html
[8]. https://pubmed.ncbi.nlm.nih.gov/36210213/
[9]. https://www.drugs.com/medical-answers/you-overdose-seroquel-3577475/#:~:text=If%20you%20think%20you%20may%20have%20taken%20too,supportive%20care%20and%20monitoring%20at%20a%20healthcare%20facility.
